Advances in Platinum Nanoparticles for cancer therapy and drug delivery
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Atena Abed,1,* Hamed Mirzaei,2
1. Shahrekord University of Medical Sciences
2. Kashan University of Medical Sciences
- Introduction: Human mortality is caused primarily by cancer, except in cases of infectious disease. Anti-cancer drugs can be improved with nanomaterials by controlling their release and increasing their in vivo efficacy. Nanoparticles (NPs) can be used as carriers for anti-cancer drugs. Antitumor properties can be conferred by metal-based nanoparticles (mNPs), including antioxidant effects. Biomedical research increasingly uses metallic nanoparticles. It is possible to design them for both therapeutic and diagnostic purposes in the case of cancer. Nanoparticles of platinum (PtNPs) are relatively new agents being investigated for cancer treatment. Cancer therapy can be improved by using therapeutic systems based on PtNPs, which result in reduced side effects and improved efficiency. One of the most valuable approaches for treating cancer is using PtNPs as an anticancer drug. A metal-based nanoparticle can enhance the effectiveness of conventional chemotherapy by releasing anticancer agents in a targeted and controlled manner. Researchers are now focusing on how to transport drugs using PtNp-based nanoplatforms. PtNps-based nanocarriers have shown promising results in many studies, in pristine form or functionalized with targeting molecules or coated with biocompatible materials. Researchers have demonstrated that in vivo stability can be improved with such nanosystems, drugs can be accumulated in tumor sites, therapeutic effectiveness can be improved, and systemic toxicity can be reduced. It is possible to produce metallic and metal oxide nanoparticles and modify them in various ways as needed. A variety of functionalization strategies may be used to conjugate them to biological molecules (antibodies, nucleic acids, peptides), targeting ligands, and anticancer drugs.
- Methods: This article is review
- Results: Nanoparticles are developing rapidly and in a variety of directions, providing alternative treatment options and improving many cancer treatments. NPs based on metals permit the delivery of anticancer agents in a controlled and targeted manner, circumventing limitations of conventional chemotherapy. As a result, carrying drugs through nanoplatforms made of platinum has become an intense research area.
- Conclusion: As nanomaterials with eco-friendly properties have been developed, they are being used in many different fields, such as biomedical engineering and drug delivery. There are many advantages to platinum NPs, such as antitumor and antibacterial activity, making them suitable candidates for a variety of pharmaceutical applications.
- Keywords: platinum nanoparticles, cancer therapy, drug delivery, cancer
