Selection of appropriate scaffolding in the process of spinal cord injury repair
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Tahereh Mehrvarz,1,* Dr. Abbas Parham,2 Dr . Hamid Mahdavi,3 Dr . Gholamreza Kaka,4
1. ferdowsi university of mashhad
2. ferdowsi university of mashhad
- Introduction: Spinal cord injury is associated with inflammation and destruction of neurons and glial cells ، With a mortality rate and disability of 25,000 to 50,000 people
The gradual destruction of the tissue around the primary trauma, known as secondary injury, also limits treatment. The cell therapy strategy is appropriate along with the selection of the scaffold
The scaffold has biodegradable and biocompatible properties and also facilitates cell cohesion
In addition, the cell environment, while controlling physical and biochemical stimuli, coordinates cellular processes, including proliferation, differentiation, movement, and apoptosis.
Therefore, a successful scaffold requires the creation of a suitable environment for cell life and its proper functioning on a small scale, and this is the direct role of the environment in which not only the cells are located, but also determines its type. Cellular behavior
The types of biomaterials used, A) Have a natural origin such as collagen, alginate, chitosan, fibrin, and hyaluronic acid
B) Synthetic origin: such as polyglycolic acid, polylactic acid, and their co-polymers C) Ceramics include calcium phosphate and bioglass d) metals such as magnesium, titanium, and selenium.
Scaffolding fabrication and shaping methods also include freeze-drying, electrospinning, solvent casting, gas foam, melt molding.
- Methods: This study is a review of articles from 2009 to 2021
Articles were selected from Science Direct and Scopus
- Results: Nanofibers support nerve regeneration, and their porous networks are very similar to the extracellular matrix. Also, spatial orientation and its structural type cause cell proliferation and differentiation
Due to the use of cells, the challenge is to choose the right polymer as well as the optimal scaffold production method that is mechanically suitable.
On the other hand, spatial orientation and scaffold configuration type are effective in the slope of cell growth and proliferation.
- Conclusion: Development and selection of scaffolding has an effective role in nerve repair
Therefore, it can be said that many scaffolds are able to cause cell adhesion but have little support for the damaged part. Natural polymers show more support. On the other hand, nanofibers are a more suitable tool for the treatment of spinal cord injury.
- Keywords: Nanofibers- spinal cord injury- Biomaterial-Electrospinning
