کتابچه خلاصه مقالات همایش


دانلود کتابچه

    The evaluation of FKBP5 regulation through Pancreatic Cancer by informatics study

  • Amirhossein Ahmadi,1 PegahJavid,2 Mansoureh Azadeh,3,* Milad Sheikh,4 Salar Keighobady,5
    1. Zist Fanavari Novin Biotechnology Department, Provincial Technical and vocational Training Organization, Isfahan, Iran
    2. Zist Fanavari Novin Biotechnology Department, Provincial Technical and vocational Training Organization, Isfahan, Iran
    3. Zist Fanavari Novin Biotechnology Department, Provincial Technical and vocational Training Organization, Isfahan, Iran
    4. Zist Fanavari Novin Biotechnology Department, Provincial Technical and vocational Training Organization, Isfahan, Iran
    5. Zist Fanavari Novin Biotechnology Department, Provincial Technical and vocational Training Organization, Isfahan, Iran


  • Introduction: Introduction. Pancreatic cancer (PAC) is the twelfth most commonly diagnosed cancer and the third leading cancer in the world. PAC, although relatively rare, is very deadly and is usually diagnosed in advanced stages. Prevention and early diagnosis are important factors in patients’ survival.
  • Methods: Methods. The GSE16515 was selected from Gene Expression Omnibus (GEO) dataset in order to detect differences in gene expression in which the experiment was performed between the two groups of tumor and normal samples. Using GeneMANIA, we obtained the highest genetic association among FKBP5, HSP90AA1 and HSP90AB1 genes.
  • Results: Results. The impaired expression of the FKBP5 gene causes glucose resistance to the insulin hormone, and this resistance eventually leads to an increase in blood sugar levels and a decrease in glycogen, the stored form of glucose. The data showed that decreased expression of FKBP5 in human adipose tissue has a potential role in glucose and lipid metabolism, adipogenesis, and type 2 diabetes (T2D). The expression level of FKBP5 gene in people with pancreatic cancer is lower than normal people and the expression of this gene in these people is 35.69 TPM while in normal people the expression of gene is 39.05 TPM. Diabetes eventually leads to unlimited growth of pancreatic cells due to dysfunctional insulin combined with glucose biosynthesis (glycogen depletion) and pancreatic cancer will accrue. This gene has a significant effect on other common cancers while upregulation such as acute myeloid leukemia and prostate adenocarcinoma. The two genes HSP90AA1 and HSP9OAB1 had the highest genetic association with FKBP5, and increased expression in these two genes causes unlimited growth of the pancreatic cells. HSP90AA1 and HSP90AB1 genes were expressed in tumor samples with 333.81 TPM and 482.37 TPM, respectively; while 93.45 TPM and 261.4 TPM were reported in normal samples.
  • Conclusion: Conclusion. It is concluded that type 2 diabetes is both a consequence and a cause of pancreatic cancer. It could be said that if a triangle is considered, the three corners of this triangle are PAC, T2D, FKBP5.
  • Keywords: Keywords: FKBP5, PAC, T2D, HSP90AA1, HSP90AB1