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    Investigating the market of derivatives tropane alkaloids and the trade of processed products

  • Zahra Morovati,1 Ghasem karimzadeh,2,* Mohammad Reza Naghavi,3 Mohamad norani,4
    1. Plant Breeding and Biotechnology Department, Faculty of Agriculture, Tarbiat Modares University
    2. Plant Breeding and Biotechnology Department, Faculty of Agriculture, Tarbiat Modares University, P.O. Box 14115-336, Tehran, Iran
    3. Department of Agronomy, Faculty of Agriculture, University of Tehran, Karaj, Iran
    4. Department of Horticultural Science, Tarbiat Modares University, Tehran, Iran


  • Introduction: The present study is a review that was collected according to the research of researchers in production and trade of medicinal and aromatic planes specially the derivatives tropane alkaloids. Medicinal and aromatic plants (MAPs) have been used for various purposes in many fields from medicine to cosmetics for thousands of years (Yildirim, 2021). In recent years, with the increasing awareness of sustainable development, environmental protection and healthy life, the production and trade of medicinal and aromatic plants has also increased. Today it is estimated that there are 422,000 plant species in the world and 50,000 of them are medicinal and aromatic plants (Shikov et al., 2021). The current global trade in medicinal plants is more than 150 $ billion, which is projected to expand to more than 450 $ billion by 2025 and by 2050 (Euromonitor, 2020). Tropane alkaloids are an important class of secondary metabolites that occur mainly in many members of the plant family Solanaceae. The Atropine, hyoscyamine and scopolamine are found in a variety of solanaceous plants including Atropa belladonna and Datura stramonium (Huang et al., 2019). Their biosynthesis occurs in the plant roots, which provides the advantage to study the biosynthesis using the plant hairy roots culture (Huang et al., 2019). Also, Most of the new tropane alkaloids were discovered in the family Solanaceae (Afewerki et al., 2019).
  • Methods: However, for the following purposes, we reviewed new articles and reputable sites; 1- Investigating the market of derivatives tropane alkaloids and the trade of processed products in the world specially in Iran 2- Possibility of producing derivatives tropane alkaloids from plant resources and if possible, their commercialization
  • Results: The results of our research show that important companies such as Sigma-Aldrich, Pharmafair, Meridian (USA), Winzer, (Denmark), Cjauvin, (France, Suisse), Stella, (Belgium, Luxembourg), Novartis, Delvin Formulations, Inga Laboratories and German Remedies Private (India) have a decisive role in the production and sale of derivatives tropane alkaloids. Capharma is the world leading manufacturer in global Atropine market with the market share of 9.19%, in terms of revenue, followed by Resonance Laboratories, Rolabo Outsourcing, Minsheng and CR Double-Crane. The global Atropine market is valued at 530.2 million USD in 2020 is expected to reach 469.6 million USD by the end of 2026. The average price of Atropine (5 ml) for current year was 60 $, Hyoscyamine (0/125 mg) was 20 $ and Hyosyne (0/125 mg) was 17 $. However, we did not obtain information and data about the production of derivatives tropane alkaloids in Iran, and there is a proper opportunity for us to produce these compounds by using the potentials of medicinal plants in Iran and by using the capabilities of plant breeding science, biotechnology and phytochemistry. Finally, we can help the country's economy by producing and exporting these products.
  • Conclusion: In conclusion, we can claim there is a proper opportunity for us to produce these compounds by using the potentials of medicinal plants in Iran and by using the capabilities of plant breeding science, biotechnology and phytochemistry. Finally, we can help the country's economy by producing and exporting these products.
  • Keywords: medicinal plants, derivatives tropane alkaloids, commercialization, Datura stramonium