The Use of Nanomedicine Against Hepatocellular Carcinoma
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Yasaman Peirovy,1,*
1. Msc of Molecular Genetic Department of Genetics, Zanjan Branch, Islamic Azad University, Zanjan, Iran.
- Introduction: The most frequent type of primary liver cancer is hepatocellular carcinoma (HCC), which is also the fifth most common cancer worldwide. It has a high mortality rate, with over 600,000 people dying each year around the world. The majority of patients are diagnosed at advanced stages of the disease, when existing therapy choices are restricted and ineffective, due to the sneaky nature of HCC's progression. Treatment for HCC is based on some criteria, including the tumor stage, the patient's performance status, and the liver's functional reserve, necessitating a multidisciplinary approach. Local ablative treatments, resection, and liver transplantation are currently available treatment options for early-stage HCC. Given the high mortality rates associated with this malignancy, it is a prominent study issue to focus on to improve treatment methods. Nanoparticles (NPs) are a diverse class of materials that have been employed to battle liver cancer in a variety of ways. Inorganic NPs such as gold, silver, platinum, metal oxide, calcium, and selenium, as well as less common compounds, have all been used in drug delivery systems as a therapeutic, carrier, or imaging agent (DDS). The purpose of this study was to investigate The Use of nanomedicine against hepatocellular carcinoma.
- Methods: The present study is titled The Use of Nanomedicine Against Hepatocellular Carcinoma which was done by searching scientific databases such as Science Direct, Springer, Google Scholar, PubMed.
- Results: Nanoparticles are beneficial in cancer therapy, according to the findings. The use of nanotechnology in cancer detection, therapy, and management has ushered in a new era. NPs increases the intracellular concentration of medications while avoiding toxicity in healthy tissue, either through active or passive targeting. To establish and regulate drug release, the targeted NPs can be created and changed to be pH-sensitive or temperature-sensitive. NPs physicochemical properties," such as shape, size, molecular mass, and surface chemistry, also play an important role in the targeted drug delivery system. Furthermore, NPs can be tailored to the target and used to target a specific moiety. Because of unequal distribution and cytotoxicity, traditional chemotherapy and radiation therapy have significant drawbacks in terms of efficacy and adverse effects. As a result, careful dosing is essential to successfully eliminate cancer cells while minimizing damage. The medicine must cross multiple fortifications before it can reach the target spot. The metabolism of drugs is a complicated process.
- Conclusion: Therefore, cutting-edge research and development in HCC nanomedicine have created a potent tool for tumor targeting that is superior to older methods. Although designing a nano-drug delivery system is a complex process that necessitates optimizing its physicochemical properties, targeting HCC cells necessitates a thorough understanding of the challenges, such as a cirrhotic liver setting and the interaction between nanoparticles and the HCC tumor environment, that are preventing its translation into clinical practice. Nanotechnology has a number of major advantages, ranging from effective targeting to reduced systemic toxicity. Surprisingly, the most important aspect of developing HCC nanomedicine is creating nanosystems with receptor-specific ligands, such as ASGPR, GPC3, TfR, FR, and SR-B1. Several in vitro and in vivo investigations have demonstrated the efficacy of nanosystems with such targeted ligands for anti-cancer treatment. As a result, progress has been made in developing particularly targeted nano delivery systems for HCC, and this method has a lot of potential for clinical application.
- Keywords: Nanomedicine, Hepatocellular Carcinoma, cancer
