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    Increased expression of glycolysis-associated genes including G6PD, STC2 and KIF20A with malignancy and poor prognosis in liver cancer patients

  • Sara Vazifehshenas,1 Elham Talebi,2 Hamid Abedinlou,3,*
    1. Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
    2. Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
    3. Department of Medical Biotechnology, Faculty of Medicine,, Kermanshah University of Medical Sciences , Kermanshah ,Iran


  • Introduction: According to the research, one of the hallmarks of cancer cells is metabolic alterations. The glycolysis pathway, rather than the oxidative phosphorylation pathway, can be used by cancer cells for energy. The purpose of this study was to explore the changes in the expression of glycolysis pathway genes and their relationship to the malignancies of liver cancer and the prognosis of patients.
  • Methods: Genes involved in the glycolysis process, which play a significant, role were discovered using a PubMed search. The alterations in the expression of potential genes relevant to the glycolysis pathway in liver cancer samples compared to normal were next analyzed using the OncoDB database, which contains transcript and clinical information produced by the cancer genome atlas. Changes in candidate gene expression were also assessed in relation to patient mortality rates. Furthermore, the association between the expression of glycolysis pathway candidate genes and clinical characteristics was evaluated.
  • Results: G6PD, STC2, and KIF20A genes discovered to be important in activating the glycolysis pathway in PubMed search results. The expression levels of these three genes increased significantly in liver cancer samples compared to normal and at least 2 times (|logFC| >1, P < 0.001). According to the results of the expression analysis, increased expression of G6PD, STC2, and KIF20A has also been linked to a poor prognosis and a high death rate (HR> 1, P < 0.01). The connection between G6PD expression and clinical characteristics revealed that G6PD expression was considerably higher in stages 2 and 3 compared to stages 1 and 4 (P < 0.01). STC2 was not linked to stage specificity, although KIF20A expression was considerably higher in stages 2 and 3 than in the other stages (P < 0.01).
  • Conclusion: Our findings revealed that the expression levels of genes implicated in the glycolysis pathway, such as G6PD, STC2, and KIF20A, increased significantly in cancer samples compared with controls, and this increased expression was related to a higher death rate. Their expression was significantly associated with the higher stages, according to the findings. Our results indicate that glycolysis pathway genes could be valuable therapeutic and diagnostic options, and that inhibiting the glycolysis process could aid patients.
  • Keywords: glycolysis pathway, G6PD, STC2, KIF20A, liver cancer