Induced Pluripotent stem cell therapy for Multiple sclerosis : a mini review
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Fatemeh Mohammadi segherlo,1,* Mohadeseh Shokrizadeh,2
1. School of Medicine, Azad University, Tehran, Iran
2. School of Medicine, Azad University, Tehran, Iran
- Introduction: Multiple sclerosis (MS) is a neurodegenerative autoimmune disease that involves young adult people. Although a large spectrum of cell therapeutic approaches for MS has been unsuccessful, some of them are useful in focal myelin disease .Induced pluripotent stem cell (IPSC) therapy is one of kinds of autologous cell transplantation therapy. First time embryonic cell of mouse and human fibroblast cell were used to generate IPSCs.
- Methods: IPSCs are somatic cells in adult individuals which can be reprogrammed by some particular factors . Moreover IPSCs have potency to convert into neural precursor cells (NPCs) and oligodendrocyte precursor cells (OPCs)
- Results: In several studies mouse IPSC-NPCs (mi IPSC-NPCs) reduced the amount of damage tissue and demyelination areas and clinical score the experimental autoimmune encephalomyelitis (EAE) .
- Conclusion: Furthermore, mi IPSC-NPCs have efficacy to protect the differentiation and survival amount of oligodendrocytes and limit the transcriptional changes related to clinical score of EAE by secreting leukemia inhibitory factor (LIF). They can decrease the blood brain barrier (BBB) damages as well as, reduce the infiltration of T cells into the neural tissue.
- Keywords: Experimental autoimmune encephalomyelitis · Induced pluripotent stem cell .Multiple sclerosis.
