Investigation of the functional relationship of MicroRNA with its related factors in cardiovascular disease: from cancer to cardiovascular
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Ali Ahmadi,1,* Mobina Sefati,2 Dariush D. Farhud,3
1. BSc. Student, Young and Elite Researchers Club, Islamic Azad University Sari Branch, Sari, Iran
2. MD. Student, Department of Medical Sciences, Faculty of Medical Sciences, Islamic Azad University Sari Branch, Sari, Iran
3. School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
- Introduction: Coronary artery disease (CHD) is a complex disease, a major threat to human health, and the leading cause of sudden cardiac death in adults worldwide. CHD occurs as an environmental and genetic factor. Only known environmental and genetic effects can explain a small part of the variability in CHD risk, which is a major barrier to its prevention and treatment, so the need for effective prevention strategies is essential. MicRNAs are also non-coding RNA molecules that act as regulators of post-genre expression Transcriptions turn off genes.MicRNAs in cardiovascular disease (CHD) have been studied as promising biomarkers for disease diagnosis, prognosis, and monitoring. Physiology, pathology, cardiac hypertrophy, and tone maintenance and response to vascular injury. MicRNAs individually as well as in a complex regulatory network affect heart growth and homeostasis. MicRNAs are identified in patients with coronary artery disease and atherosclerosis. However, their association with risk factors Cardiovascular, including hyperlipidemia, hypertension, obesity, diabetes, inactivity, and smoking is unclear. This study investigates the role of microRNAs and their interaction with environmental factors in CHD and aims to investigate the role of MicRNAs as markers. New bio-potential for cardiovascular disease.
- Methods: This secondary study with the Narrative Review approach, in 2022 by searching for keywords such as MicroRNA, Neoplasm, Primary MicroRNA, Hypertrophies, Biology Markers, Coronary Heart Disease and Atherosclerosis in the MESH database as well as valid databases between Internationally, PubMed, Science Direct, Web of Science and Scopus. This study was finally reviewed by extracting 15 articles, of which 10 articles were included in the study
- Results: Based on studies from various studies, the results are that multiple microRNAs (miRs) are small RNAs that target multiple pathways. High and regular daily exercise significantly reduced the risk of CHD. The data showed that a light diet was significantly associated with a reduced risk of CHD, while a family history of CHD, anxiety, and alcohol consumption was significantly associated with an increased risk of CHD. Two types of MicRNA (miR-126) And miR-148) in combination with several risk factors could have played a common role in the development of CHD. Therefore, it is necessary to manage patients with CHD in all directions and on multiple levels. CHD was associated with changes in MicRNA expression profiles as well as risk factors, such as abnormal lipid metabolism. Thus, miRNAs may be potential biomarkers of CHD. However, there are limitations to the use of MicRNAs. These include costs and several confounding factors that may affect the MicRNA profile.
- Conclusion: According to the results, a better understanding of the key processes that lead to pathophysiological changes that underlie the disease is of great importance. Many miRNAs are also expressed in the fetal heart after birth and in adults. Their abnormal expression or genetic deletion is associated with abnormal differentiation of heart cells, impaired heart growth, and impaired heart function. A considerable body of evidence suggests that miRNAs are involved in the development of CVD and suggest them as attractive diagnostic biomarkers and therapeutic tools.
- Keywords: MicroRNA, Neoplasm, Primary MicroRNA, Hypertrophies, Biology Markers, Coronary Heart Disease and Ath
