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دانلود کتابچه

    Synthesis and Characterization of Artemisinin-Chitosan/Alginate Nanoparticles as a Drug delivery System for Prostate Cancer Treatment

  • Mona Moghadami,1 Fatemeh Tohidi1,2,* Ali Taravati,3
    1. Department of Medical Biotechnology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
    3. Department of Molecular and Cell Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran


  • Introduction: Background: Prostate cancer remains as the most frequently diagnosed malignancy in men worldwide. Conventional treatments such as radiation therapy and chemotherapy are undesirable due to the adverse effects on healthy cells and drug resistance. Artemisinin, a natural compound derived from Artemisia annua, also known as sweet wormwood, is an effective anti-malaria agent that has recently been found to have anti-cancer effects on prostate cancer. However, its poor water solubility, low bioavailability, and short half-life are the main drawbacks for its use in the clinic. Objective: This study was aimed to fabricate chitosan/alginate nanoparticles as a biocompatible, hydrophilic and low toxic drug delivery system to improve the therapeutic efficiency of artemisinin.
  • Methods: Methods: Artemisinin-loaded nanoparticles were prepared by ionotropic gelation procedure. The encapsulation efficiency of chitosan/alginate loaded with artemisinin was determined by spectrophotometric assays. Dynamic light scattering (DLS(, Fourier Transform-Infra Red spectroscopy (FTIR), and Field Emission Scanning Electron Microscopy (FE-SEM) techniques were used to characterize the nanoparticles in terms of structure, size, zeta potential, hydrodynamic diameter and morphology. Release profile of artemisinin from the was studied at pH 5.5, and 7.4.
  • Results: Results: The results showed the encapsulation efficiency and of 61%. The nanoparticles average size obtained from FE-SEM ranged from 30-40 nm with a spherical shape that was optimum for drug delivery. DLS results indicated that zeta potential and hydrodynamic diameter were -45.7 mv and 293.5 nm, respectively. FTIR analysis confirmed the interaction of artemisinin with chitosan/alginate nanoparticles. Drug release indicated an initial fast release followed by a sustained release of 48.30% and 54.71% at pH 5.5 and pH 7.5 after 48 h, respectively.
  • Conclusion: Conclusion: It could be concluded that Cs/Alg NPs would be a potential carrier of ART for the treatment of prostate cancer.
  • Keywords: Artemisinin, Prostate Cancer, Nanoparticles, Chitosan/Alginate