Stop angiogenesis using plant nanoemulsions
-
fereshteh rouygar,1,* Shafieh Abdullahzadeh,2 Mohammad Hossein Sayadi,3
1. Birjand University
2. Birjand University
3. Birjand University
- Introduction: Angiogenesis plays an important role in physiological (embryogenesis) and pathological conditions (some diseases, including cancer).
Nanotechnology in the last decade has had a wide impact on various areas of human life, including pharmacy and medicine. In recent years, much attention has been paid to the preparation of polymer nanoparticles as drug carriers because nanoparticles can be used as a drug delivery system due to controlling and slowing down drug release, smaller particle size than the cell, biocompatibility and increasing therapeutic efficacy of the drug. To be considered very effective.
- Methods: Encapsulation of anti-angiogenic compounds and their use to seal the angiogenic process in the fight against various diseases has been considered by many researchers.
Therefore, in many studies, silver nanoparticles are used to reduce the process of angiogenesis, but in principle, these structures are unpredictable due to their chemical composition, lipophilic properties, catalytic activity, etc. Nanoparticle structures, despite their very small size, over time may lead to leukocyte poisoning by entering these cells, as well as indirect damage to DNA and more.
Therefore, plant nanoemulsions should be used to better control angiogenesis.
- Results: Black cumin extract is one of the most widely used extracts, which includes cumin aldehyde, paracetamol, alpha-phenine and gamma-terpene, which are often terpene compounds that have biological effects in the pharmaceutical and food industries.
Also, vegetable oils are a good candidate for the treatment of some diseases, including cancer, due to their phenolic compounds.
- Conclusion: Studies have shown that nanoemulsions synthesized from plants have toxic effects on the cell, which leads to inhibition of cell proliferation and ultimately leads to the cessation of angiogenesis, mimic angiogenesis.
- Keywords: Angiogenesis,, nanoparticles, plant emulsions,,cumin, tomur
