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    Production of moisturizing cream using Nostoc cyanobacteria and its antibacterial effects

  • Somayeh Sadat Naghibi Avanji,1,* Mozghan Emtiazjoo,2 Solmaz Shahlla,3
    1. Somayeh Sadat Naghibi Avanji , Master Student , Azad University, Central Tehran Branch
    2. Dr.Mozghan Emtyazjoo Associate Professor Azad University, North Tehran Branch
    3. Dr.Solmaz Shahlla Assistant Professor, Azad University, Central Tehran Branch.


  • Introduction: Following the increasing bacterial resistance to common commercial antibiotics, the trend The use of natural compounds with antibacterial and antimicrobial properties has increased and cyanobacteria are a good source of sunscreens and moisturizers. Currently, the global production of microalgae and cyanobacteria is mainly aimed at high value-added applications as algal biomass contains pigments, proteins, fatty acids, polysaccharides, vitamins and minerals, all of which are of interest. They have a lot to do with natural products, both in food and in cosmetics. Therefore, in this study, the possibility of producing moisturizing cream by Nostoc cyanobacteria and studying its antibacterial effects on Pseudomonas aeruginosa has been investigated.
  • Methods: Nostoc cyanobacteria were collected from the coastal and southern parts of the Caspian Sea in the direction of water flow. And growth of Nostoc cyanobacterial strain of Zindro liquid extraction medium was prepared by aqueous, methanolic and hexane methods. Bacterial culture was performed in nutrient agar medium and Müller Hinton agar medium and half McFarland tube was used to standardize the microbial suspension protection. Took. Then, the extraction of hydrocolloids and the intention of the hygienic cream formulation and the amount of hydration were performed using different concentrations, and then the results were read by the Detolite digital hand microscope, model AM211.
  • Results: The results of the present study showed that the effect of Nostoc cyanobacterial extracts on Pseudomonas aeruginosa was such that the diameter of the growth inhibition zone was 20 mm in aqueous extract, 30 mm in methanolic extract and 25 mm in hexane extract, as methanolic extract was the most abundant. It has an inhibitory effect on bacterial growth and has caused the death of Pseudomonas aeruginosa. The lowest concentration as the minimum concentration of bacterial growth inhibitor was 0.6 mg / ml and the same concentration was obtained in the study of the minimum lethal concentration.
  • Conclusion: It should be noted that the lowest growth inhibitory concentration was observed in hexane extract 0.59 and in aqueous extract 0.55 mg / ml. In one gram of cream, the skin has the highest amount of hydration, and the properties and characteristics of creams produced by creams such as viscosity and pH increased with increasing duration of use. Also, the largest size of the growth inhibition halo is related to the combined sample of the produced cream and the hydrocolloid of Cyanobacter Nostoc. The size of the non-growth halo diameter of the composite sample in the disk diffusion method is 25 mm larger than the diameter of the halo created in the well drilling method is 23 mm. 0.49 mg / ml and the composition of the cream produced and the hydrocolloid Cyanobacterium nostoc is equal to 0.38 mg / ml. Therefore, it can be acknowledged that Cyanobacterium nostok has a good antibacterial effect against Pseudomonas aeruginosa.
  • Keywords: Antibacterial, Cyanobacterium nostoc, Pseudomonas aeruginosa and Moisturizing Cream.