کتابچه خلاصه مقالات همایش


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    Disorders of Long Non-Coding RNAs (lncRNA) in Neurodegenerative Diseases of the CNS

  • Fereshteh Behdarvand,1,* Marziyeh Akbari,2
    1. Young Researchers Club, shahrekord Branch, Islamic Azad University
    2. Department of Genetics, Faculty of Basic Science


  • Introduction: Introduction: The development and homeostasis of the central nervous system (CNS) are controlled by epigenetic mechanisms. These mechanisms modulate gene activity and enhance the selective arrangement of functional gene networks in the neural terminal response to the complex activities of environmental signals. Therefore, it is not surprising that disorders in the epigenetic process cause a range of mental and neurological disorders. Epigenetic mechanisms include DNA methylation and a variety of histone changes controlled by long non-coding RNAs. While the biological functions of many lncRNAs have not yet been fully elucidated. But recent research shows that lncRNAs play a key role in determining cellular identity. This function seems to be important for the arrangement of glial cells and nerve neurons in the CNS.
  • Methods: This review performed by searching lncRNAs, neurodegenerative diseases of the CNS, and epigenetic mechanisms keywords in various internet databases such as PubMed, and Google Scholar.
  • Results: The results showed recognition of the factors affecting the activity and function of lncRNAs in the CNS, followed by epigenetic changes.
  • Conclusion: Conclusion: Also in this article tries to address the factors that disrupt lncRNAs as one of the important factors in various CNS pathologies including neurological disorders and diseases, neuro-immunological problems and nerve growth, primary brain tumors, and mental illnesses. Recognition of pathogenesis and factors affecting these diseases can be used for therapeutic purposes.
  • Keywords: Keywords: lncRNA, Epigenetic Mechanisms, Neurological Disorders, CNS