The place of individual genetics in susceptibility to COVID-19
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Tohid Javaheri,1,*
1. Department of Biology, University Campus 2, University of Guilan, Rasht, Iran
- Introduction: Covid19 has recently spread widely as a complex disease and epidemic around the world. Although most people with the disease are elderly or have major medical problems such as cardiovascular disease, high blood pressure, diabetes, or cancer, some of the victims are healthy and even relatively young and in different age groups. The sequence of patients' genomes for disease-related DNA alterations helps explain this mystery. Genetic changes in genes related to immune function, including human leukocyte antigen (HLA), are emerging as an important determinant of Covid19 infection. One of the ways the SARS-COV-2 virus enters the ACE2 receptor, Therefore, the genetic variants of the ACE2 receptor can be another important factor in the genetic susceptibility to Covid19.
- Methods: In this review study, searches were performed in the electronic and scientific databases of PubMed, Medline, Google Scholar, Scopus, and ISI, and valid articles related to the subject were searched using the keywords genetics, immunology, and COVID-19.
- Results: The results of studying genetic findings in different communities and the susceptibility of people to this disease will be an important step to help personal and predictive medicine.
- Conclusion: The purpose of this study is to show the place of individual genetics in susceptibility to COVID-19, which requires extensive and more research in this field and allows researchers and physicians to use the information obtained to manufacture effective drugs and vaccines.
- Keywords: Genetics, Immunology, Covid19, Personal medicine
