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دانلود کتابچه

    The Role of Cancers on the COVID-19 Incidence and Outcomes: A comprehensive review study of the current knowledge

  • Mina AkbariRad,1,* AmirAli Moodi Ghalibaf,2
    1. Associate Professor of Internal Medicine, Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
    2. Student Research Committee, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran


  • Introduction: Today the novel coronavirus disease (COVID-19) had become a great worldwide disaster. During the pandemic, cancer patients are a high-risk group in getting the infection and have severe outcomes. In the current study, we performed a systematic review to determine the COVID-19’s outcomes severity in cancer patients.
  • Methods: A comprehensive systematic search was conducted in electronic databases including Embase, Pubmed, Scopus, and Web of science with the keywords “Cancer”, “COVID-19” and all other related MeSH terms up to December 2021. Cohort studies that investigated the cancer patients in comparison with non-cancer patients were included in this review, the studies that did not mention cancer patients' outcomes of COVID-19’s infection were excluded.
  • Results: According to the included studies (n=11), the analysis of 5,619 patients (2,032 with active cancer) determined that cancer patients are significantly more likely to admit to the ICU and the mortality rate is higher in them. Being male and receiving received any cancer therapy within 4 weeks before the onset of the COVID-19 symptoms blurts severer outcomes of the disease in comparison with the patients who did not do any cancer therapy. Chemotherapy was the most common therapeutic method was done for cancer patients and an obvious relationship was observed between the chemotherapy and the COVID-19’s outcomes severity; In the other words, chemotherapy could be a risk factor for the outcomes severity and deaths due to COVID-19. Interestingly, the studies expressed that immunosuppressive therapies may not worsen the outcomes of COVID-19, however, this could be due to treatment side effects. Moreover, patients with breast cancer were the most probable group of cancer patients in getting COVID-19 infection.
  • Conclusion: Due to our systematic study, there are more severe outcomes of COVID-19 in cancer patients, in comparison with non-cancer patients, and more attention is needed.
  • Keywords: COVID-19, Cancer, Cancer Therapy